Given Mai's weapon is a spear, she favors mid-ranged combat. With her longer reach zoning attacks, keep the opponent at bay, then use Juncture when you see the opponent let their guard down. Furthermore, Mai does not have a → + Normal Attack, nor does she have many routes to take in her combo path. Her controls are rather simple compared to others. Instead she can use Variable Arts. Variable Arts is a similar system to Revolver Action, but it allows you to string actions together, even when one misses.
During Variable Arts, C is Mai's main zoning tool. At mid-range, connect into it from a standing attack. Standing A → C is quick and effective. Next chain that attack into quick overhead follow-up A. If the opponent blocks while standing, close the distance with Juncture, and use a Crouching A. When you want to close the distance, Standing A → C → B or, the enhanced version of Suzuran: Blaze is effective. Both leave you with an advantage, even if the opponent blocks, so they are excellent tools.
If you're close to the opponent, connect into a Variable Arts B. Continue to press B, and Mai will transition into a stance where she lifts one leg off the ground. During this, use her Overheads ↑ + A or C, or her Low, A or C to break through opponent's guards. Against opponents that attack from midair, Crouching C is effective. If the opponent is farther away, Juncture, then go into a Himeyuri: Dipper or the anti-air Sylvan Hurricane Assault to shut them down. If you let the opponent get in really close, use a Barrier Block to spread the distance, followed by a Moon Blossom to rest the situation.
If you have Heat to spare, Floral Blizzard Blossom is extremely useful. You are able to block your opponent's attack, so use it with confidence. 
|Normal Input||Alternative Input|
|Takes a deep stance and throws a spear. Charging it will allow Mai to change her stance and make the spear unblockable. Input ↓ or ↑ to alter the spear's trajectory|
| Flurry of the Winter Moon
|A + B + C + D|
|Shortens the charging time for drive attacks|
| Shearing Cherry Blossom Storm
|During OD, A + B + C + D|
| → Himeyuri
|↓↘→ + A or A during Juncture|
| → Himeyuri: Blaze
|→↓↘ + B or B during Juncture|
| → Himeyuri: Dipper
|↓↘→ + C or C during Juncture|
| Moon Blossom
|↓↙←||↓ + SP|
| → Suzuran
|↓↙← + A (midair also) or A during Moon Blossom|
| → Suzuran: Blaze
|↓↙← + B (midair also) or B during Moon Blossom|
| → Suzuran: Dipper
|↓↙← + C (midair also) or C during Moon Blossom|
| Sylvan Hurricane Assault
|↓→↘ + D (midair also) (uses 50% Heat)|
| Floral Blizzard Blossom
|↓↙← + D (delayable) (uses 50% Heat)||← + SP (uses 50% Heat)|
| Royal Crimson Sprout: "New Moon Lotus"
|↓↓↓ + D (uses 100% Heat)|
- Juncture (刹梛 Setsuna) is read as "juncture" but written with the characters for "temple" and "evergreen tree."
- Himeyuri (姫百璃) is read as "lily" but written with the last character replaced with one for "lapis lazuli."
- Suzuran (須寿蘭) is read as "lily of the valley" but written with the characters for necessity, longevity, and orchid respectively.
- BlazBlue: Central Fiction, Tutorial Mode, Character Specifics, Mai Natsume, Lesson 03: Strategy Lessons